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Among the many treasures in Cushing’s Brain Tumor Registry are the photographs he took of his patients, before and after surgery. Many of the patients were photographed with one of their hands showing. The hands took on importance in the photographs because many diseases affect the size and shape of the hands—they may be small in pituitary dwarfism and large in acromegaly, a hormonal disorder caused by a benign tumor of the pituitary gland that affects adults in their early 20s. Not all photographs have been matched to patient records. The boy at left is believed to have a pituitary tumor.