Michael J Caplan PhD, MD

C. N. H. Long Professor of Cellular and Molecular Physiology and Professor of Cell Biology; Chair, Cellular and Molecular Physiology

Departments & Organizations

Yale Combined Program in the Biological and Biomedical Sciences (BBS): Molecular Cell Biology, Genetics and Development | Molecular Medicine, Pharmacology, and Physiology

LCME Faculty Subcommittee

Office of Student ResearchCell Biology: Membrane Traffic | Cellular & Molecular Physiology: Membrane Proteins - Pumps and Transporters; Membrane Protein Sorting and Trafficking; Epithelial Transport of Ions and Solutes; Organ Physiology; Physiology of Human Disease; Graduate Program in Cellular and Molecular PhysiologyCenter for Polycystic Kidney Disease Research


Michael J. Caplan received his bachelors degree from Harvard University and his M.D. and Ph.D. degrees from Yale University in 1987. He joined Yale's Department of Cellular and Molecular Physiology as a faculty member in 1988, and is currently the C.N.H. Long Professor of Cellular and Molecular Physiology and Cell Biology.

He has received fellowships from the Helen Hay Whitney Foundation, the David and Lucille Packard Foundation for Science and Engineering, and a National Young Investigator Award from the National Science Foundation. He has also received the Young Investigator Awards from the American Physiological Society and the American Society of Nephrologists.

His work focuses on understanding the ways in which kidney cells organize and maintain their unique structures. His laboratory also studies the mechanisms responsible for Autosomal Dominant Polycystic Kidney Disease, and is working to identify targets for new therapies.


  • Ph.D., Yale University , 1987
  • M.D., Yale University , 1987

Selected Publication

  • Grimm DH, Cai Y, Chauvet V, Rajendran V, Zeltner R, Geng L, Avner ED, Sweeney W, Somlo S, Caplan MJ. Polycystin-1 distribution is modulated by polycystin-2 expression in mammalian cells. J Biol Chem, 278:36786-36793, 2003.

Latest Honor and Recognition

  • Charles W. Bohmfalk Teaching Prize, Yale School of Medicine
Download on the Apple App Store