David G. Schatz PhD

Professor of Immunobiology; Professor of Molecular Biophysics and Biochemistry

Departments & Organizations

Biological and Biomedical Sciences (BBS): Immunology: Computational Immunology | Molecular Cell Biology, Genetics and Development | Biochemistry, Biophysics and Structural Biology

Cancer Immunology

Immunobiology: Lymphocyte Development

Immunology and Immunotherapy

Research Interests

Biochemical mechanism and developmental regulation of V(D)J recombination and somatic hypermutation; lymphocyte development; mechanisms of DNA repair; function of the RAG1 and RAG2 proteins; mechanisms of lymphomagenesis more...

Education

• Ph.D., Massachusetts Institute of Technology, 1990

Selected Publications

• Ji, Y., Resch, W., Corbett, E., Yamane, A., Casellas, R., and Schatz, D.G. (2010). The in vivo pattern of binding of RAG1 and RAG2 to antigen receptor loci. Cell 141, 419-431.
• Liu, M., Duke, J. L., Richter, D. J., Vinuesa, C. G., Goodnow, C. C., Kleinstein, S. H. and Schatz, D. G. Two levels of protection for the B cell genome during somatic hypermutation. Nature 451, 841-845 (2008)
• Yin, F.F., Bailey, S., Innis, C.A., Ciubotaru, M., Kamtekar, S., Steitz, T.A., and Schatz, D.G. (2009). Structure of the RAG1 nonamer binding domain with DNA reveals a dimer that mediates DNA synapsis. Nat Struct Mol Biol 16, 499-508.

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