Fred Gorelick MD

Professor of Medicine (Digestive Diseases) and of Cell Biology; Deputy Director, Yale M.D., Ph.D. Program

Departments & Organizations

Yale Combined Program in the Biological and Biomedical Sciences (BBS): Molecular Cell Biology, Genetics and Development

LCME Academic Environment Subcommittee

Office of Student ResearchCell Biology: Membrane TrafficInternal Medicine: Digestive Diseases


After completing medical school and internal medicine training at the University of Missouri, Dr. Gorelick trained at Yale in Gastroenterology. Afterhis clinical training, he began basic science training with Dr. James Jamieson at Yale. During that period he described calcium-calmodulin dependent protein kinase II and subsequently worked with Dr. Paul Greengard (Rockefeller University) to examines the enzyme's mechanism of activation, a response critical to memory.

His later work has focused on the mechanisms of acute pancreatits and how digestive enzymes, such as trypsin, are activated within the pancreas during this disease. Dr. Gorelick sees patients with gastrointestinal diseases at the VAMC in West Haven, CT. He is also the Deputy Director for the Yale physician Scientist program and directs a year-long course for the group that links basic science to clinical disease. He laboratory at the VA studies the molecular mechanisms related to acute pancreatitis with a goal of developing tools that prevent or lessen disease.


  • M.D., University of Missouri , 1973

Selected Publication

  • Cerulein hyperstimulation decreases AMP-activated protein kinase levels at the site of maximal zymogen activation. Shugrue CA, Alexandre M, de Villalvilla AD, Kolodecik TR, Young LH, Gorelick FS, Thrower EC. Am J Physiol Gastrointest Liver Physiol. 2012 Sep 15;303(6):G723-32

Latest Honor and Recognition

  • ASCI(1990) , Amer Soc Clin Investigation
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